Difloxacin

• CAT Number: I015361
• CAS Number: 98106-17-3
• Molecular Formula: C₂₁H₁₉F₂N₃O₃
• Molecular Weight: 399.39
• Purity: ≥95%
• Target: Bacterial
• IUPAC Name: 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
• InChI: InChI=1S/C21H19F2N3O3/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14/h2-5,10-12H,6-9H2,1H3,(H,28,29)
• InChIKey: NOCJXYPHIIZEHN-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F

Difloxacin（Cat No.:I015361）is a fluoroquinolone antibiotic used primarily in veterinary medicine to treat bacterial infections in animals, particularly respiratory, urinary, and gastrointestinal infections. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription, leading to bacterial cell death. Effective against a broad range of gram-negative and some gram-positive bacteria, Difloxacin is valued for its potency and relatively low toxicity. Its once-daily dosing and broad-spectrum activity make it a practical choice in managing infections in companion animals, particularly dogs and cats.

Reference

[1]. E A Gorzynski, et al. Comparative Antimycobacterial Activities of Difloxacin, Temafloxacin, Enoxacin, Pefloxacin, Reference Fluoroquinolones, and a New Macrolide, Clarithromycin. Antimicrob Agents Chemother. 1989 Apr;33(4):591-2.