For research use only. Not for therapeutic Use.
Dihydro montelukast is a potential impurity found in commercial montelukast preparations. Montelukast (sodium salt) (Item No. <span class=/itemid/>10008318</span>) is a potent and selective cysteinyl leukotriene 1 (CysLT<sub>1</sub>) receptor antagonist. Formulations containing montelukast are used for the treatment of asthma as well as for the symptoms associated with allergic rhinitis.
| Catalog Number | R067125 |
| CAS Number | 142147-67-9 |
| Synonyms | 1-[[[(1R)-1-[3-[2-(7-chloro-2-quinolinyl)ethyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-cyclopropaneacetic acid |
| Molecular Formula | C35H38ClNO3S |
| Purity | ≥95% |
| Storage | 2°C to 8°C |
| IUPAC Name | 2-[1-[[(1R)-1-[3-[2-(7-chloroquinolin-2-yl)ethyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid |
| InChI | InChI=1S/C35H38ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-9,11-12,14,16,20-21,32,40H,10,13,15,17-19,22-23H2,1-2H3,(H,38,39)/t32-/m1/s1 |
| InChIKey | QYOIIAUGMZLCEO-JGCGQSQUSA-N |
| SMILES | CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)CCC3=NC4=C(C=CC(=C4)Cl)C=C3)SCC5(CC5)CC(=O)O)O |
| Reference | 1.Leff, J.A.,Busse, W.W.,Pearlman, D., et al. Montelukast, a leukotriene-receptor antagonist, for the treatment of mild asthma and exercise-induced brochoconstriction. N. Engl. J. Med. 339(3), 147-152 (1998). |
