Dihydrochelerythrine

• CAT Number: I004586
• CAS Number: 6880-91-7
• Molecular Formula: C21H19NO4
• Molecular Weight: 349.38
• Purity: ≥95%
• Target: Fungal
• Solubility: 10 mM in DMSO
• Storage: 2-8°C
• IUPAC Name: 1,2-dimethoxy-12-methyl-13H-[1,3]benzodioxolo[5,6-c]phenanthridine
• InChI: InChI=1S/C21H19NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-9H,10-11H2,1-3H3
• InChIKey: ALZAZMCIBRHMFF-UHFFFAOYSA-N
• SMILES: CN1CC2=C(C=CC(=C2OC)OC)C3=C1C4=CC5=C(C=C4C=C3)OCO5

Dihydrochelerythrine（Cat No.:I004586）is a benzophenanthridine alkaloid derived from natural plant sources, known for its diverse pharmacological activities. It exhibits antimicrobial, anti-inflammatory, and anticancer properties by targeting various cellular pathways, including inhibition of protein kinase C (PKC). Its potential to modulate cell signaling makes it a valuable compound in cancer research, particularly for inducing apoptosis in tumor cells. Additionally, dihydrochelerythrine shows promise in combating bacterial and fungal infections. Current studies focus on its synthesis, bioactivity optimization, and therapeutic applications in addressing infectious and chronic diseases.

Reference

[1]. Feng G, et al. Inhibitory activity of dihydrosanguinarine and dihydrochelerythrine against phytopathogenic fungi. Nat Prod Res. 2011 Jul;25(11):1082-9.

[2]. Vrba J, et al. Chelerythrine and dihydrochelerythrine induce G1 phase arrest and bimodal cell death in human leukemia HL-60 cells. Toxicol In Vitro. 2008 Jun;22(4):1008-17.

[3]. Tantapakul C, et al. Antibacterial compounds from Zanthoxylum rhetsa. Arch Pharm Res. 2012 Jul;35(7):1139-42.