For research use only. Not for therapeutic Use.
Dihydrocurcumin, a major metabolites of curcumin, reduces lipid accumulation and oxidative stress. Dihydrocurcumin regulates mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increases protein expression levels of pAKT and PI3K, and reduced the levels of cellular NO and ROS via Nrf2 signaling pathways[1].
Dihydrocurcumin (0-50 μM, 24 h) decreases OA induced TG level in HepG2 and L02 cells[1].
Dihydrocurcumin (0-50 μM, 24 h) promotes glucose uptake and reduces the levels of cellular NO and ROS[1].
| Catalog Number | I046100 |
| CAS Number | 76474-56-1 |
| Synonyms | (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-4,6-dien-3-one |
| Molecular Formula | C21H22O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H22O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3,5-7,9-13,22,24-25H,4,8H2,1-2H3/b7-3+,16-13- |
| InChIKey | BWHPKBOLJFNCPW-YJNULWIISA-N |
| SMILES | COC1=C(C=CC(=C1)CCC(=O)C=C(C=CC2=CC(=C(C=C2)O)OC)O)O |
| Reference | [1]. Yu Q, et al. Dihydrocurcumin ameliorates the lipid accumulation, oxidative stress and insulin resistance in oleic acid-induced L02 and HepG2 cells. Biomed Pharmacother. 2018 Jul;103:1327-1336. |
