For research use only. Not for therapeutic Use.
(-)-Dihydroguaiaretic acid is a Lipoxygenase inhibitor that has antioxidant activity. (-)-Dihydroguaiaretic acid inhibits the oxidation of unsaturated fatty acids and removes free radicals. (-)-Dihydroguaiaretic acid also has anticancer activity with an IC50 value of 7.49 μM (A549 cells)[1][2].
| Catalog Number | I041923 |
| CAS Number | 124649-78-1 |
| Synonyms | 4-[(2R,3R)-4-(4-hydroxy-3-methoxyphenyl)-2,3-dimethylbutyl]-2-methoxyphenol |
| Molecular Formula | C20H26O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H26O4/c1-13(9-15-5-7-17(21)19(11-15)23-3)14(2)10-16-6-8-18(22)20(12-16)24-4/h5-8,11-14,21-22H,9-10H2,1-4H3/t13-,14-/m1/s1 |
| InChIKey | ADFOLUXMYYCTRR-ZIAGYGMSSA-N |
| SMILES | CC(CC1=CC(=C(C=C1)O)OC)C(C)CC2=CC(=C(C=C2)O)OC |
| Reference | [1]. Yamauchi S, et al. Antioxidant activity of butane type lignans, secoisolariciresinol, dihydroguaiaretic acid, and 7,7′-oxodihydroguaiaretic acid. Biosci Biotechnol Biochem. 2008 Nov;72(11):2981-6. [2]. Davis R A, et al. Isolation, structure elucidation and cytotoxic evaluation of endiandrin B from the Australian rainforest plant Endiandra anthropophagorum[J]. Bioorganic & medicinal chemistry, 2009, 17(3): 1387-1392. |
