For research use only. Not for therapeutic Use.
Dihydrolycorine, isolated from Lycoris radiate Herb, is an inhibitor of protein synthesis in eukarytic cells by inhibiting the peptide bone formation step[1][2].
Dihydrolycorine inhibits methoxamine-induced contraction of isolated rabbit aortic rings and rat anococcygeus muscle with pA2 values of 5.93 and 6.35, respectively[2].
| Catalog Number | R072485 |
| CAS Number | 6271-21-2 |
| Synonyms | (1S,15R,17S,18S,19R)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9-triene-17,18-diol |
| Molecular Formula | C16H19NO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H19NO4/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19/h4-5,8,11,14-16,18-19H,1-3,6-7H2/t8-,11+,14+,15-,16-/m1/s1 |
| InChIKey | VJILFEGOWCJNIK-MGRBZGILSA-N |
| SMILES | C1CN2CC3=CC4=C(C=C3C5C2C1CC(C5O)O)OCO4 |
| Reference | [1]. Jimenez A, et al. Inhibitors of protein synthesis in eukarytic cells. Comparative effects of some amaryllidaceae alkaloids. Biochim Biophys Acta. 1976 Mar 17;425(3):342-8. [2]. Chen BY, et al. [Hypotensive effect of dihydrolycorine]. Zhongguo Yao Li Xue Bao. 1993 Jan;14(1):45-9. |
