Dihydrorotenone

For research use only. Not for therapeutic Use.

  • CAT Number: I017931
  • CAS Number: 6659-45-6
  • Molecular Formula: C₂₃H₂₄O₆
  • Molecular Weight: 396.43
  • Purity: ≥95%
Inquiry Now

Dihydrorotenone(Cat No.:I017931)is a natural organic compound derived from the roots of Derris and Lonchocarpus plants, known for its potent inhibition of mitochondrial complex I in the electron transport chain. By blocking this complex, dihydrorotenone disrupts ATP production and induces oxidative stress, making it a useful tool in cellular and neurotoxicity studies, particularly for research into Parkinson’s disease and other neurodegenerative conditions. Its role in inducing mitochondrial dysfunction allows researchers to study energy metabolism impairment, apoptosis, and the effects of oxidative stress, contributing to our understanding of mitochondrial-related pathologies.


Catalog Number I017931
CAS Number 6659-45-6
Molecular Formula C₂₃H₂₄O₆
Purity ≥95%
Storage Store at -20°C
IUPAC Name (1S,6R,13S)-16,17-dimethoxy-6-propan-2-yl-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one
InChI InChI=1S/C23H24O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,11,16,20-21H,8,10H2,1-4H3/t16-,20-,21+/m1/s1
InChIKey DTFARBHXORYQBF-HBGVWJBISA-N
SMILES CC(C)[C@H]1CC2=C(O1)C=CC3=C2O[C@@H]4COC5=CC(=C(C=C5[C@@H]4C3=O)OC)OC
Reference

[1]. Zhang J, et al. The natural pesticide dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway. PLoS One. 2013 Jul 26;8(7):e69911.

Request a Quote