For research use only. Not for therapeutic Use.
Dihydrorotenone(Cat No.:I017931)is a natural organic compound derived from the roots of Derris and Lonchocarpus plants, known for its potent inhibition of mitochondrial complex I in the electron transport chain. By blocking this complex, dihydrorotenone disrupts ATP production and induces oxidative stress, making it a useful tool in cellular and neurotoxicity studies, particularly for research into Parkinson’s disease and other neurodegenerative conditions. Its role in inducing mitochondrial dysfunction allows researchers to study energy metabolism impairment, apoptosis, and the effects of oxidative stress, contributing to our understanding of mitochondrial-related pathologies.
Catalog Number | I017931 |
CAS Number | 6659-45-6 |
Molecular Formula | C₂₃H₂₄O₆ |
Purity | ≥95% |
Storage | Store at -20°C |
IUPAC Name | (1S,6R,13S)-16,17-dimethoxy-6-propan-2-yl-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one |
InChI | InChI=1S/C23H24O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,11,16,20-21H,8,10H2,1-4H3/t16-,20-,21+/m1/s1 |
InChIKey | DTFARBHXORYQBF-HBGVWJBISA-N |
SMILES | CC(C)[C@H]1CC2=C(O1)C=CC3=C2O[C@@H]4COC5=CC(=C(C=C5[C@@H]4C3=O)OC)OC |
Reference | [1]. Zhang J, et al. The natural pesticide dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway. PLoS One. 2013 Jul 26;8(7):e69911. |