Dihydrosanguinarine

• CAT Number: I003321
• CAS Number: 3606-45-9
• Molecular Formula: C20H15NO4
• Molecular Weight: 333.34
• Purity: ≥95%
• Target: Fungal
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: 24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-1(13),2,4(8),9,11,14(22),15,17(21)-octaene
• InChI: InChI=1S/C20H15NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-7H,8-10H2,1H3
• InChIKey: CIUHLXZTZWTVFL-UHFFFAOYSA-N
• SMILES: CN1CC2=C(C=CC3=C2OCO3)C4=C1C5=CC6=C(C=C5C=C4)OCO6

Dihydrosanguinarine（Cat No.:I003321）is a naturally occurring alkaloid derived from Sanguinaria canadensis, a plant known for its medicinal properties. It exhibits various biological activities, including antimicrobial, anti-inflammatory, and anticancer effects. Dihydrosanguinarine has been studied for its potential in cancer therapy, particularly in inhibiting tumor cell proliferation and inducing apoptosis. Its antimicrobial properties make it useful in treating infections, and it has shown promise in modulating signaling pathways related to inflammation. As a bioactive compound, Dihydrosanguinarine continues to be of interest for its therapeutic potential across multiple research domains.

Reference

[1]. Vrba J, et al. Cytotoxic activity of sanguinarine and dihydrosanguinarine in human promyelocytic leukemia HL-60 cells. Toxicol In Vitro. 2009 Jun;23(4):580-8.

[2]. Feng G, et al. Inhibitory activity of dihydrosanguinarine and dihydrochelerythrine against phytopathogenic fungi. Nat Prod Res. 2011 Jul;25(11):1082-9.

[3]. Vrublova E, et al. The toxicity and pharmacokinetics of dihydrosanguinarine in rat: a pilot study. Food Chem Toxicol. 2008 Jul;46(7):2546-53.

[4]. Fuchino H, et al. In vitro leishmanicidal activity of benzophenanthridine alkaloids from Bocconia pearcei and related compounds. Chem Pharm Bull (Tokyo). 2010 Aug;58(8):1047-50.