For research use only. Not for therapeutic Use.
Dihydrosphingosine (Cat.No:I010293) is a naturally occurring sphingolipid molecule found in cell membranes. It plays a crucial role in various cellular processes, including cell signaling, apoptosis, and lipid metabolism. Dihydrosphingosine is being studied for its potential therapeutic applications in the treatment of cancer, neurodegenerative disorders, and skin conditions. Further research is ongoing to explore its biological functions and therapeutic potential.
| Catalog Number | I010293 |
| CAS Number | 3102-56-5 |
| Synonyms | Alternative Name: Sphinganine |
| Molecular Formula | C18H39NO2 |
| Purity | ≥95% |
| Target | TGF-beta/Smad |
| Solubility | Soluble to 100 mM in DMSO |
| Storage | Store at -20℃ |
| IUPAC Name | 2-aminooctadecane-1,3-diol |
| InChI | InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3 |
| InChIKey | OTKJDMGTUTTYMP-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCCCC(C(CO)N)O |
| Reference | <br>1. H. Fyrst et al. “Characterization of free endogenous C14 and C16 sphingoid bases from Drosophila melanogaster” Journal of Lipid Research, vol. 45 pp.54-62, 2004<br>2. W. Zheng “Fenretinide increases dihydroceramide and dihydrosphingolipids due to inhibition of dihydroceramide desaturase” Georgia Institute ofTechnology, 2006<br>3. L. van der Westhuizen et al. “Sphingoid base levels in humans consuming fumonisin-contaminated maize in rural areas of the former Transkei, SouthAfrica: a cross-sectional study” Food Additives and Contaminants, Vol. 25(11), pages 1385 – 1391, 2008<br>4. Shih-Hsuan Hsiao et al. “Effects of Exogenous Sphinganine, Sphingosine, and Sphingosine-1-Phosphate on Relaxation and Contraction of PorcineThoracic Aortic and Pulmonary Arterial Rings” Toxicological Sciences, Vol. 86(1) Pp. 194-199, 2005</br></br></br></br> |
