For research use only. Not for therapeutic Use.
Dihydrotachysterol is a synthetic analog of vitamin D. Dihydrotachysterol can be used to for the research of hypocalcemia (lack of calcium in the blood) and hypoparathyroidism (lack of parathyroid hormone in the body) [1][2].
Dihydrotachysterol is effective in the elevation of serum calcium by stimulating intestinal calcium absorption and mobilizing bone calcium in the absence of parathyroid hormone and of functioning renal tissue[1].
Dihydrotachysterol also increases renal phosphate excretion[1].
Dihydrotachysterol is a potent synthetic vitamin D analogue that is widely available but more expensive than vitamin D2. It has an onset of action and half-life between those of vitamin D2 and calcitriol. Dihydrotachysterol (initially given at 0.03 to 0.08 mg/kg/day for 2 to 3 days. The final dosages range from 0.004 to 0.04 mg/kg/day) is useful for the treatment of hypoparathyroidism[2].
| Catalog Number | R013523 |
| CAS Number | 67-96-9 |
| Synonyms | (1S,3E,4S)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylcyclohexan-1-ol |
| Molecular Formula | C28H46O |
| Purity | ≥95% |
| InChI | InChI=1S/C28H46O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h9-10,12-13,19-22,25-27,29H,7-8,11,14-18H2,1-6H3/b10-9+,23-12+,24-13+/t20-,21-,22+,25-,26+,27-,28+/m0/s1 |
| InChIKey | ILYCWAKSDCYMBB-OPCMSESCSA-N |
| SMILES | CC1CCC(CC1=CC=C2CCCC3(C2CCC3C(C)C=CC(C)C(C)C)C)O |
| Reference | [1]. I Quack, et al. Dihydrotachysterol therapy for hypoparathyroidism: consequences of inadequate monitoring. Five cases and a review. Exp Clin Endocrinol Diabetes. 2005 Jul;113(7):376-80. [2]. M E Peterson, et al. Idiopathic hypoparathyroidism in five cats. J Vet Intern Med. Jan-Feb 1991;5(1):47-51. |
