Dihydrotanshinone I

• CAT Number: I005251
• CAS Number: 87205-99-0
• Molecular Formula: C18H14O3
• Molecular Weight: 278.3
• Purity: ≥95%
• Solubility: DMSO
• Storage: Store at -20°C

Dihydrotanshinone I (CAT: I005251) is a natural diterpene quinone compound found in the root of Salvia miltiorrhiza, commonly known as Danshen. It possesses diverse pharmacological activities and has been extensively studied for its potential therapeutic applications. Dihydrotanshinone I exhibits notable cardiovascular effects by promoting vasodilation, inhibiting platelet aggregation, and reducing myocardial injury. It also displays anticancer properties by inducing apoptosis, inhibiting cell proliferation, and suppressing tumor growth. Furthermore, dihydrotanshinone I demonstrate anti-inflammatory and antioxidant activities, making it a potential candidate for the treatment of inflammatory diseases. Ongoing research aims to explore its full therapeutic potential and mechanisms of action.

Reference

[1]. Zhao W, et al. Dihydrotanshinone I Attenuates Atherosclerosis in ApoE-Deficient Mice: Role of NOX4/NF-κB Mediated Lectin-Like Oxidized LDL Receptor-1 (LOX-1) of the Endothelium. Front Pharmacol. 2016 Nov 8;7:418. eCollection 2016.

[2]. Wei Y, et al. The cardioprotection of dihydrotanshinone I against myocardial ischemia-reperfusion injury via inhibition of arachidonic acid ω-hydroxylase. Can J Physiol Pharmacol. 2016 Dec;94(12):1267-1275. Epub 2016 Jun 24.

[3]. Wang L, et al. Dihydrotanshinone I induced apoptosis and autophagy through caspase dependent pathway in colon cancer. Phytomedicine. 2015 Nov 15;22(12):1079-87.