For research use only. Not for therapeutic Use.
Neurotensin (NT) and dopamine (DA) receptor antagonist; dipeptide neuroleptic of potential efficacy in relieving positive and negative symptoms of schizophrenia
| Catalog Number | I047583 |
| CAS Number | 200954-39-8 |
| Molecular Formula | C21H30N2O5 |
| Purity | ≥95% |
| IUPAC Name | methyl (2S)-2-[[(2S)-1-hexanoylpyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoate |
| InChI | InChI=1S/C21H30N2O5/c1-3-4-5-8-19(25)23-13-6-7-18(23)20(26)22-17(21(27)28-2)14-15-9-11-16(24)12-10-15/h9-12,17-18,24H,3-8,13-14H2,1-2H3,(H,22,26)/t17-,18-/m0/s1 |
| SMILES | CCCCCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)OC |
| Reference | MV Retyunskaya et al. Neuromodulatory mechanism underlying the effect of the atypical dipeptide neuroleptic dilept. Bull. Exp. Biol Med. 2003, 136(5), 467-470.
RU Ostrovskaia et al. Dilept: a tripeptoid neurotensin analog combining neuroleptic activity with positive mnemotropic action. Eksp. Klin. Farmakol. 2005, 68(1), 3-6.
RU Ostrovskaia et al. Neurotensine dipeptide analog dilept decreases the deficiency of prestimulus startle reflex inhibition: a prognostic sign of antipsychotic activity. Eksp. Klin. Farmakol. 2009, 72(5), 3-7. |
