For research use only. Not for therapeutic Use.
Diloxanide is a luminal amebicide used in the treatment of amebiasis. It is considered the luminal agent of choice for mild intestinal amebiasis or asymptomatic cyst carriers. It can also be added to metronidazole (active drug in luminal and extraintestinal amebiasis) in acute amebic dysentery as well as hepatic abscess (In hepatic abscess it is for the control of cysts in the lumen which may cause relapse).
| Catalog Number | R033393 |
| CAS Number | 579-38-4 |
| Synonyms | 2,2-Dichloro-N-(4-hydroxyphenyl)-N-methylacetamide; 2,2-Dichloro-4’-hydroxy-N-methylacetanilide; Ame-boots; Amebamida; Dichloro-N-4-hydroxyphenyl-N-methylacetamide; Diloxanid; Entamide; N-Dichloroacetyl-N-methyl-p-hydroxyaniline; RD 3803; ? |
| Molecular Formula | C9H9Cl2NO2 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | 2,2-dichloro-N-(4-hydroxyphenyl)-N-methylacetamide |
| InChI | InChI=1S/C9H9Cl2NO2/c1-12(9(14)8(10)11)6-2-4-7(13)5-3-6/h2-5,8,13H,1H3 |
| InChIKey | GZZZSOOGQLOEOB-UHFFFAOYSA-N |
| SMILES | CN(C1=CC=C(C=C1)O)C(=O)C(Cl)Cl |
| Reference | </br>1:Development and Optimization of HPLC Analysis of Metronidazole, Diloxanide, Spiramycin and Cliquinol in Pharmaceutical Dosage Forms Using Experimental Design. Elkhoudary MM, Abdel Salam RA, Hadad GM.J Chromatogr Sci. 2016 Nov;54(10):1701-1712. Epub 2016 Sep 12. PMID: 27621138 </br>2:Enhancement of site specific delivery of diloxanide furoate as an antiamoebic drug. Tiwari V, Verma S, Verma SK, Dangi JS.Eur J Pharm Sci. 2016 Apr 30;86:50-7. doi: 10.1016/j.ejps.2016.03.001. Epub 2016 Mar 4. PMID: 26952868 </br>3:Comparative artificial neural network and partial least squares models for analysis of Metronidazole, Diloxanide, Spiramycin and Cliquinol in pharmaceutical preparations. Elkhoudary MM, Abdel Salam RA, Hadad GM.Spectrochim Acta A Mol Biomol Spectrosc. 2014 Sep 15;130:222-9. doi: 10.1016/j.saa.2014.04.002. Epub 2014 Apr 13. PMID: 24792195 </br>4:Kinetic spectrophotometric H-point standard addition method for the simultaneous determination of diloxanide furoate and metronidazole in binary mixtures and biological fluids. Issa MM, Nejem RM, Abu Shanab AM, Shaat NT.Spectrochim Acta A Mol Biomol Spectrosc. 2013 Oct;114:592-8. doi: 10.1016/j.saa.2013.05.062. Epub 2013 Jun 5. PMID: 23807049 </br>5:Development and application of a novel, dual-mode gradient, stability-indicating HPLC-DAD method for the simultaneous determination and purity assessment of mebeverine hydrochloride, diloxanide furoate and their corresponding major degradation products in combination with some gastrointestinal drugs in the form of oral doses. Mabrouk M, El-Fatatry H, Hewala I, Emam E.J Pharm Biomed Anal. 2013 Sep;83:249-59. doi: 10.1016/j.jpba.2013.04.013. Epub 2013 Apr 19. PMID: 23770637 </br>6:Simultaneous determination of diloxanide furoate and metronidazole in presence of diloxanide furoate degradation products. Abbas SS, Wagieh NE, Abdelkawy M, Abdelrahman MM.J AOAC Int. 2011 Sep-Oct;94(5):1427-39. PMID: 22165007 </br>7:RPLC Determination of Tinidazole and Diloxanide Furoate in Tablets. Pai PN, Rao GK, Srinivas B, Puranik S.Indian J Pharm Sci. 2008 Sep;70(5):670-2. doi: 10.4103/0250-474X.45415. PMID: 21394273 Free PMC Article</br>8:Con-A conjugated mucoadhesive microspheres for the colonic delivery of diloxanide furoate. Anande NM, Jain SK, Jain NK.Int J Pharm. 2008 Jul 9;359(1-2):182-9. doi: 10.1016/j.ijpharm.2008.04.009. Epub 2008 Apr 12. PMID: 18486369 </br>9:Stability indicating reversed-phase liquid chromatographic determination of metronidazole benzoate and diloxanide furoate as bulk drug and in suspension dosage form. Mishal A, Sober D.J Pharm Biomed Anal. 2005 Sep 15;39(3-4):819-23. PMID: 16055294 </br>10:Stability studies on diloxanide furoate: effect of pH, temperature, gastric and intestinal fluids. Gadkariem EA, Belal F, Abounassif MA, El-Obeid HA, E E Ibrahim K.Farmaco. 2004 Apr;59(4):323-9. PMID: 15081350 |
