DIM-C-pPhOCH3

• CAT Number: I020319
• CAS Number: 33985-68-1
• Molecular Formula: C₂₄H₂₀N₂O
• Molecular Weight: 352.43
• Purity: ≥95%
• Target: Nuclear Hormone Receptor 4A/NR4A

DIM-C-pPhOCH3 (CAT: I0203191) is a Nur77 agonist, targeting the orphan nuclear receptor nerve growth factor-induced Bα (NGFI-Bα, Nur77). In RKO colon cancer cells, DIM-C-pPhOCH3 induces apoptosis and decreases cell survival. It increases the expression of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) protein and triggers several markers of apoptosis, including PARP cleavage and caspase activation. In animal studies, DIM-C-pPhOCH3 inhibits tumor growth in mice bearing RKO cell xenografts, leading to reduced tumor volumes and weights. These findings suggest that DIM-C-pPhOCH3 may have the potential as an anticancer agent.

Reference

[1]. Cho SD, et al. Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways. Cancer Res. 2007 Jan 15;67(2):674-83.