For research use only. Not for therapeutic Use.
Dimaprit dihydrochloride is a selective histamine H2 receptor agonist, it also inhibits nNOS with an IC50 of 49 μM. Dimaprit dihydrochloride can stimulate gastric acid secretion[1][2].
Dimaprit has less than 0.0001% the activity of histamine on H1-receptors[1].
Dimaprit (0.1 nM-100 μM) inhibits nNOS concentration dependently with an IC50 of 49±14 μM[2].
Dimaprit stimulates gastric acid secretion in rats (1.25 μM/kg/min; rapid i.v. injection), cats (2-64 μM/h; i.v.) and dogs (1-100 nM/kg/min; i.v.)[1].
Dimaprit (0.01-1 μM/kg; i.v. at intervals of 5 min) causes dose-dependent falls in blood pressure in cats. Dimaprit (1-100 nM; intra-arterial injection) causes vasodilatation in the femoral vascular bed, and it (1 μM/kg; bolus or intravenous injection) has no effect on heart rate[1].
| Catalog Number | I010223 |
| CAS Number | 23256-33-9 |
| Synonyms | 3-(dimethylamino)propyl carbamimidothioate;dihydrochloride |
| Molecular Formula | C6H17Cl2N3S |
| Purity | ≥95% |
| InChI | InChI=1S/C6H15N3S.2ClH/c1-9(2)4-3-5-10-6(7)8;;/h3-5H2,1-2H3,(H3,7,8);2*1H |
| InChIKey | DFWCPLGXFMSUCW-UHFFFAOYSA-N |
| SMILES | CN(C)CCCSC(=N)N.Cl.Cl |
| Reference | [1]. Parsons ME, et, al. Dimaprit -(S-[3-(N,N-dimethylamino)prophyl]isothiourea) – a highly specific histamine H2 -receptor agonist. Part 1. Pharmacology. Agents Actions. 1977 Mar; 7(1): 31-7. [2]. Paquay JB, et, al. Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br J Pharmacol. 1999 May; 127(2): 331-4. |
