Dimemorfan phosphate

• CAT Number: I020485
• CAS Number: 36304-84-4
• Molecular Formula: C₁₈H₂₈NO₄P
• Molecular Weight: 353.39
• Purity: ≥95%
• Target: Sigma Receptor
• IUPAC Name: (1S,9S,10S)-4,17-dimethyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene;phosphoric acid
• InChI: 1S/C18H25N.H3O4P/c1-13-6-7-14-12-17-15-5-3-4-8-18(15,16(14)11-13)9-10-19(17)2;1-5(2,3)4/h6-7,11,15,17H,3-5,8-10,12H2,1-2H3;(H3,1,2,3,4)/t15-,17+,18+;/m1./s1
• InChIKey: ODJHDWLIOUGPPA-URVXVIKDSA-N
• SMILES: CC1=CC2=C(C[C@H]3[C@@H]4[C@]2(CCCC4)CCN3C)C=C1.OP(=O)(O)O

Dimemorfan phosphate (Cat No.: I020485) is a centrally acting antitussive (cough suppressant) that works by modulating the cough reflex in the brain without the sedative or addictive effects associated with opioid-based agents. It is structurally related to morphinan derivatives but lacks opioid receptor activity, making it a safer alternative for managing non-productive cough. Dimemorfan also exhibits mild neuroprotective and anti-inflammatory properties, contributing to its therapeutic interest. It is commonly used in over-the-counter and prescription cough medications in several countries for respiratory symptom relief.

Reference

[1]. Shin EJ, et al. Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice. Behav Brain Res. 2004 May 5;151(1-2):267-76.[2]. Wang YH, et al. Anti-inflammatory effects of dimemorfan on inflammatory cells and LPS-induced endotoxin shock in mice. Br J Pharmacol. 2008 Jul;154(6):1327-38.