For research use only. Not for therapeutic Use.
Dimethindene (Cat No.:I006389), also known as Z-2001, is an antihistamine/anticholinergic drug that is used orally and topically as an antipruritic.
| Catalog Number | I006389 |
| CAS Number | 5636-83-9 |
| Synonyms | Z 2001; Z2001; Z-2001; Dimethindene; Dimetindene; Dimetindeno;N,N-dimethyl-2-(3-(1-(pyridin-2-yl)ethyl)-1H-inden-2-yl)ethanamine |
| Molecular Formula | C20H24N2 |
| Purity | ≥95% |
| Target | Immunology/Inflammation |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine |
| InChI | InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3 |
| InChIKey | MVMQESMQSYOVGV-UHFFFAOYSA-N |
| SMILES | CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C |
| Reference | </br>1:Contact dermatitis and secondary systemic allergy to dimethindene maleate. Leroy A, Baeck M, Tennstedt D.Contact Dermatitis. 2011 Mar;64(3):170-1. doi: 10.1111/j.1600-0536.2010.01830.x. No abstract available. PMID: 21272026 </br>2:Application of HILIC stationary phase to determination of dimethindene maleate in topical gel. Matysová L, Havlíková L, Hájková R, Krivda A, Solich P.J Pharm Biomed Anal. 2009 Aug 15;50(1):23-6. doi: 10.1016/j.jpba.2009.03.032. Epub 2009 Apr 5. PMID: 19394784 </br>3:Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: application to (R)-dimethindene occupancy of central histamine H1 receptors. Malany S, Hernandez LM, Smith WF, Crowe PD, Hoare SR.J Recept Signal Transduct Res. 2009;29(2):84-93. doi: 10.1080/10799890902721339. PMID: 19308787 </br>4:Determination of dimethindene enantiomers in pharmaceuticals by capillary electrophoresis with carboxyethyl-beta-cyclodextrin. Mikus P, Kubacák P, Valásková I, Havránek E.Pharmazie. 2007 Jan;62(1):31-3. PMID: 17294809 </br>5:Comparison of capillary zone electrophoresis and isotachophoresis determination of dimethindene enantiomers in pharmaceuticals using charged carboxyethyl-beta-cyclodextrin as a chiral selector. Mikus P, Kubacak P, Valaskova I, Havranek E.Methods Find Exp Clin Pharmacol. 2006 Nov;28(9):595-9. PMID: 17200724 </br>6:[Dimethindene determination in various dosage forms by means of capillary isotachophoresis]. Kubacák P, Mikus P, Valásková I, Havránek E.Ceska Slov Farm. 2005 Sep;54(5):231-4. Slovak. PMID: 16209438 </br>7:[Prescription and safety of dimethindene maleate micropellet capsules in Hungary]. Mikó P.Orv Hetil. 2004 Feb 15;145(7):327-9. Hungarian. PMID: 15049047 </br>8:Effects of dimethindene maleate nasal spray on the quality of life in seasonal allergic rhinitis. Kirchhoff CH, Kremer B, Haaf-von Below S, Kyrein HJ, Mösges R.Rhinology. 2003 Sep;41(3):159-66. PMID: 14579656 </br>9:Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists. Böhme TM, Keim C, Kreutzmann K, Linder M, Dingermann T, Dannhardt G, Mutschler E, Lambrecht G.J Med Chem. 2003 Feb 27;46(5):856-67. PMID: 12593665 </br>10:Mechanistic study of opposite migration order of dimethindene enantiomers in capillary electrophoresis in the presence of native beta-cyclodextrin and heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin. Chankvetadze B, Pintore G, Burjanadze N, Bergenthal D, Bergander K, Breitkreuz J, Mühlenbrock C, Blaschke G.J Chromatogr A. 2000 Apr 14;875(1-2):455-69. PMID: 10839165 |
