For research use only. Not for therapeutic Use.
Dimethindene maleate is a histamine H1 antagonist. It is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.
| Catalog Number | R044747 |
| CAS Number | 3614-69-5 |
| Synonyms | N,N-Dimethyl-3-[1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine (2Z)-2-Butenedioate;?N,N-Dimethyl-3-[1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine (Z)-2-Butenedioate;2-[1-[2-(dimethylaminoethyl)inden-3-yl]ethyl]-pyridine Maleate; 2-[1-[2-[2-(Dimethylamin |
| Molecular Formula | C24H28N2O4 |
| Purity | ≥95% |
| Target | Immunology/Inflammation |
| Storage | -20°C |
| IUPAC Name | (Z)-but-2-enedioic acid;N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine |
| InChI | InChI=1S/C20H24N2.C4H4O4/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20;5-3(6)1-2-4(7)8/h4-10,12,15H,11,13-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChIKey | SWECWXGUJQLXJF-BTJKTKAUSA-N |
| SMILES | CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C.C(=CC(=O)O)C(=O)O |
| Reference | </br>1:Contact dermatitis and secondary systemic allergy to dimethindene maleate. Leroy A, Baeck M, Tennstedt D.Contact Dermatitis. 2011 Mar;64(3):170-1. doi: 10.1111/j.1600-0536.2010.01830.x. No abstract available. PMID: 21272026 </br>2:Application of HILIC stationary phase to determination of dimethindene maleate in topical gel. Matysová L, Havlíková L, Hájková R, Krivda A, Solich P.J Pharm Biomed Anal. 2009 Aug 15;50(1):23-6. doi: 10.1016/j.jpba.2009.03.032. Epub 2009 Apr 5. PMID: 19394784 </br>3:[Prescription and safety of dimethindene maleate micropellet capsules in Hungary]. Mikó P.Orv Hetil. 2004 Feb 15;145(7):327-9. Hungarian. PMID: 15049047 </br>4:Effects of dimethindene maleate nasal spray on the quality of life in seasonal allergic rhinitis. Kirchhoff CH, Kremer B, Haaf-von Below S, Kyrein HJ, Mösges R.Rhinology. 2003 Sep;41(3):159-66. PMID: 14579656 </br>5:Dimethindene maleate in the treatment of sunburn. A double-blind, placebo-controlled pilot study. Schaffler K, Beckers C, Unkauf M, Kyrein HJ.Arzneimittelforschung. 1999 Apr;49(4):374-9. PMID: 10337458 </br>6:Protective effects of topically coadministered dimethindene maleate and cinnamic acid derivatives against ultraviolet light. Blazsó G, Hilbert M, Hegyes P, Megyeri A, Gábor M.Pharmazie. 1998 Jun;53(6):425-6. No abstract available. PMID: 9675775 </br>7:Dimethindene maleate in the treatment of pruritus caused by varizella zoster virus infection in children. Englisch W, Bauer CP.Arzneimittelforschung. 1997 Nov;47(11):1233-5. PMID: 9428981 </br>8:Effects of dimethindene maleate on psychomotor performance in the oculodynamic test compared with placebo and loratadine. Englisch W, Rehn D, Schaffler K, Wauschkuhn CH.Arzneimittelforschung. 1996 Sep;46(9):887-90. PMID: 8876938 </br>9:Efficacy of intranasally applied dimethindene maleate solution as spray in adult volunteers with symptoms of seasonal allergic rhinitis in the Vienna challenge chamber. Kyrein HJ, Horak F, Nirnberger G, Rehn D.Arzneimittelforschung. 1996 Aug;46(8):794-9. PMID: 9125281 </br>10:Double protective effect of topically applied dimethindene maleate against ultraviolet light. Blazsò G, Hilbert M, Gábor M.Pharmazie. 1996 Jul;51(7):516-7. No abstract available. PMID: 8774844 |
