For research use only. Not for therapeutic Use.
Dimethylfraxetin is a Carbonic anhydrase inhibitor, with a Ki value of 0.0097 μM.
At CA I there is one stand out compound being Dimethylfraxetin (compound 17), a nanomolar CA I inhibitor. This trimethoxy coumarin is the most potent of any of the NP coumarins across the six CA isozymes of the present study[1].
| Catalog Number | R003665 |
| CAS Number | 6035-49-0 |
| Synonyms | 6,7,8-trimethoxychromen-2-one |
| Molecular Formula | C12H12O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H12O5/c1-14-8-6-7-4-5-9(13)17-10(7)12(16-3)11(8)15-2/h4-6H,1-3H3 |
| InChIKey | RAYQKHLZHPFYEJ-UHFFFAOYSA-N |
| SMILES | COC1=C(C(=C2C(=C1)C=CC(=O)O2)OC)OC |
| Reference | [1]. Davis RA, et al. Natural product coumarins that inhibit human carbonic anhydrases. Bioorg Med Chem. 2013 Mar 15;21(6):1539-43. |
