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536-71-0-Diminazene free base Diminazene free base

Diminazene free base

For research use only. Not for therapeutic Use.

  • CAT Number: I026207
  • CAS Number: 536-71-0
  • Molecular Formula: C14H15N7
  • Molecular Weight: 281.32
  • Purity: 98%
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Related Small Molecules: L-Lysine ethyl ester dihydrochloride     AMD-070 hydrochloride     Mal-​PEG4-​NHS ester    

Diminazene Free Base (Cat.No:I026207) is an antiprotozoal agent used primarily in veterinary medicine. It is effective against various parasites, including Babesia and Trypanosoma species. Diminazene Free Base works by interfering with the DNA and RNA metabolism of the parasites, leading to their elimination. 


Catalog Number I026207
CAS Number 536-71-0
Synonyms

Diminazene Free Base

Molecular Formula C14H15N7
Purity 98%
Solubility To be determined
Appearance Solid powder
Storage Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
IUPAC Name 4-[2-(4-carbamimidoylphenyl)iminohydrazinyl]benzenecarboximidamide
InChI InChI=1S/C14H15N7/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18/h1-8H,(H3,15,16)(H3,17,18)(H,19,20)
InChIKey XNYZHCFCZNMTFY-UHFFFAOYSA-N
SMILES C1=CC(=CC=C1C(=N)N)NN=NC2=CC=C(C=C2)C(=N)N
Reference

1: da Silva Oliveira GL, de Freitas RM. Diminazene aceturate–An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics. Pharmacol Res. 2015 Dec;102:138-57. doi: 10.1016/j.phrs.2015.10.005. Epub 2015 Oct 22. PMID: 26470648.
2: Peregrine AS, Mamman M. Pharmacology of diminazene: a review. Acta Trop. 1993 Sep;54(3-4):185-203. doi: 10.1016/0001-706x(93)90092-p. PMID: 7902657.
3: Kuriakose S, Uzonna JE. Diminazene aceturate (Berenil), a new use for an old compound? Int Immunopharmacol. 2014 Aug;21(2):342-5. doi: 10.1016/j.intimp.2014.05.027. Epub 2014 Jun 2. PMID: 24893117.
4: Nixon SA, Saez NJ, Herzig V, King GF, Kotze AC. The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro. Vet Parasitol. 2019 Jun;270:40-46. doi: 10.1016/j.vetpar.2019.05.008. Epub 2019 May 19. PMID: 31213240.
5: Silva de Almeida TC, Lanza K, da Silva Filha R, C Campos LMC, Fonseca EG, Chagas MW, Rocha NP, de Sá MA, Vieira MAR, Caliari MV, Kangussu LM, Ferreira AJ, Simões E Silva AC. ACE2 activator diminazene aceturate exerts renoprotective effects in gentamicin-induced acute renal injury in rats. Clin Sci (Lond). 2020 Dec 11;134(23):3093-3106. doi: 10.1042/CS20201022. PMID: 33206153.
6: Tuvshintulga B, Sivakumar T, Yokoyama N, Igarashi I. Development of unstable resistance to diminazene aceturate in Babesia bovis. Int J Parasitol Drugs Drug Resist. 2019 Apr;9:87-92. doi: 10.1016/j.ijpddr.2019.02.001. Epub 2019 Feb 13. PMID: 30785049; PMCID: PMC6382846.
7: Odeniran PO, Macleod ET, Ademola IO, Welburn SC. Suspected resistance of Trypanosoma species to diminazene aceturate on a cattle farm in Nigeria. Trop Anim Health Prod. 2019 Sep;51(7):2091-2094. doi: 10.1007/s11250-019-01902-5. Epub 2019 Apr 17. PMID: 30997632.
8: Badae NM, El Naggar AS, El Sayed SM. Is the cardioprotective effect of the ACE2 activator diminazene aceturate more potent than the ACE inhibitor enalapril on acute myocardial infarction in rats? Can J Physiol Pharmacol. 2019 Jul;97(7):638-646. doi: 10.1139/cjpp-2019-0078. Epub 2019 Mar 6. PMID: 30840489.
9: Castardeli C, Sartório CL, Pimentel EB, Forechi L, Mill JG. The ACE 2 activator diminazene aceturate (DIZE) improves left ventricular diastolic dysfunction following myocardial infarction in rats. Biomed Pharmacother. 2018 Nov;107:212-218. doi: 10.1016/j.biopha.2018.07.170. Epub 2018 Aug 6. PMID: 30092400.
10: Velkoska E, Patel SK, Burrell LM. Angiotensin converting enzyme 2 and diminazene: role in cardiovascular and blood pressure regulation. Curr Opin Nephrol Hypertens. 2016 Sep;25(5):384-95. doi: 10.1097/MNH.0000000000000254. PMID: 27367913.

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