DiMNF

• CAT Number: R059768
• CAS Number: 14756-24-2
• Molecular Formula: C21H16O4
• Molecular Weight: 332.35
• Purity: ≥95%
• Synonyms: 2-(3,4-dimethoxyphenyl)benzo[h]chromen-4-one
• InChI: InChI=1S/C21H16O4/c1-23-18-10-8-14(11-20(18)24-2)19-12-17(22)16-9-7-13-5-3-4-6-15(13)21(16)25-19/h3-12H,1-2H3
• InChIKey: QDZQDIUUJDAORK-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3)OC

DiMNF (3′,4′-Dimethoxy-αNF) is a selective aryl hydrocarbon receptor (AHR) modulator. DiMNF is a competitive AHR ligand (IC50 = 21 nM) with apparent antagonistic activity. DiMNF can be used as an anti-inflammatory agent[1].
DiMNF (3′,4′-Dimethoxy-αNF) (10 μM; 4 h) minimally influences AHR gene battery[1].
DiMNF (10 μM; 1 h) effectively suppresses cytokine-mediated inflammatory gene expression[1].
DiMNF adopts a unique orientation within the ligand binding pocket of AHR[1].

Reference

[1]. Murray IA, et al. Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3′,4′-dimethoxy-α-naphthoflavone. Mol Pharmacol. 2011 Mar;79(3):508-19.
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