For research use only. Not for therapeutic Use.
Diphyllin（Cat No.:I015303）is a plant-derived compound with potential therapeutic applications, particularly in the treatment of respiratory disorders. It acts as a bronchodilator by relaxing the smooth muscles of the airways, making it useful for conditions such as asthma and chronic obstructive pulmonary disease (COPD). Additionally, Diphyllin possesses mild anti-inflammatory and antispasmodic properties, contributing to its overall efficacy in managing respiratory conditions. As a natural alkaloid, it is being explored for its potential in drug development, especially for patients seeking alternative treatments with fewer side effects than conventional medications.
| Catalog Number | I015303 |
| CAS Number | 22055-22-7 |
| Molecular Formula | C₂₁H₁₆O₇ |
| Purity | ≥95% |
| Target | Membrane Transporter/Ion Channel |
| IUPAC Name | 9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-3H-benzo[f][2]benzofuran-1-one |
| InChI | InChI=1S/C21H16O7/c1-24-15-6-11-12(7-16(15)25-2)20(22)13-8-26-21(23)19(13)18(11)10-3-4-14-17(5-10)28-9-27-14/h3-7,22H,8-9H2,1-2H3 |
| InChIKey | VMEJANRODATDOF-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C2C(=C1)C(=C3C(=C2O)COC3=O)C4=CC5=C(C=C4)OCO5)OC |
| Reference | [1]. Xin-Ya Xu, et al. Anti-HIV Lignans From Justicia Procumbens. Chin J Nat Med. 2019 Dec;17(12):945-952.<br>[2]. Mette G Sørensen, et al. Diphyllin, a Novel and Naturally Potent V-ATPase Inhibitor, Abrogates Acidification of the Osteoclastic Resorption Lacunae and Bone Resorption. J Bone Miner Res. 2007 Oct;22(10):1640-8.<br>[3]. Yerra Koteswara Rao, et al. Anti-inflammatory Activities of Constituents Isolated From Phyllanthus Polyphyllus. J Ethnopharmacol. 2006 Jan 16;103(2):181-6. |
