For research use only. Not for therapeutic Use.
DIPQUO is an activator of the bone marker alkaline phosphatase (ALP), with an EC50 of 6.27 μM in C2C12 cells. DIPQUO promotes mouse and human osteoblast differentiation via activation of p38 MAPK-β[1].
| Catalog Number | I018978 |
| CAS Number | 1269365-82-3 |
| Synonyms | 6,8-dimethyl-3-(4-phenyl-1H-imidazol-5-yl)-1H-quinolin-2-one |
| Molecular Formula | C20H17N3O |
| Purity | ≥95% |
| InChI | InChI=1S/C20H17N3O/c1-12-8-13(2)17-15(9-12)10-16(20(24)23-17)19-18(21-11-22-19)14-6-4-3-5-7-14/h3-11H,1-2H3,(H,21,22)(H,23,24) |
| InChIKey | KTMBLNYSLKFCIR-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C2C(=C1)C=C(C(=O)N2)C3=C(N=CN3)C4=CC=CC=C4)C |
| Reference | [1]. Cook B, et al. Discovery of a Small Molecule Promoting Mouse and Human Osteoblast Differentiation via Activation of p38 MAPK-β. Cell Chem Biol. 2019 Mar 29. |
