For research use only. Not for therapeutic Use.
Diquafosol Tetrasodium, also known as Diquas and INS-365, is a P2Y2 purinoceptor receptor agonist that stimulates the secretion of mucins from ocular tissues Diquafosol tetrasodium improves tear film stability and visual function.
| Catalog Number | I006494 |
| CAS Number | 211427-08-6 (tetrasodium) |
| Synonyms | Diquafosol Tetrasodium; INS-365; DE-089; KPY-998; INS 365; DE 089; KPY 998; INS365; DE089; KPY998; Diquas;Uridine 5/’-(pentahydrogen tetraphosphate), P/’/’/’-5/’ester with uridine, tetrasodium salt |
| Molecular Formula | C18H22N4Na4O23P4 |
| Purity | ≥95% |
| Target | P2Y Receptor |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | tetrasodium;[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate |
| InChI | InChI=1S/C18H26N4O23P4.4Na/c23-9-1-3-21(17(29)19-9)15-13(27)11(25)7(41-15)5-39-46(31,32)43-48(35,36)45-49(37,38)44-47(33,34)40-6-8-12(26)14(28)16(42-8)22-4-2-10(24)20-18(22)30;;;;/h1-4,7-8,11-16,25-28H,5-6H2,(H,31,32)(H,33,34)(H,35,36)(H,37,38)(H,19,23,29)(H,20,24,30);;;;/q;4*+1/p-4/t7-,8-,11-,12-,13-,14-,15-,16-;;;;/m1..../s1 |
| InChIKey | OWTGMPPCCUSXIP-FNXFGIETSA-J |
| SMILES | C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])OP(=O)([O-])OCC3C(C(C(O3)N4C=CC(=O)NC4=O)O)O)O)O.[Na+].[Na+].[Na+].[Na+] |
| Reference | </br>1:Comparison of cytotoxicities and wound healing effects of diquafosol tetrasodium and hyaluronic acid on human corneal epithelial cells. Lee JH, Lee JS, Kim S, Lee JE.Korean J Physiol Pharmacol. 2017 Mar;21(2):189-195. doi: 10.4196/kjpp.2017.21.2.189. Epub 2017 Feb 21. PMID: 28280412 Free PMC Article</br>2:The Effect of Topical Diquafosol Tetrasodium 3% on Dry Eye After Cataract Surgery. Baek J, Doh SH, Chung SK.Curr Eye Res. 2016 Oct;41(10):1281-1285. Epub 2016 Apr 6. PMID: 27049809 </br>3:Diquafosol Tetrasodium Increases the Concentration of Mucin-like Substances in Tears of Healthy Human Subjects. Shigeyasu C, Hirano S, Akune Y, Yamada M.Curr Eye Res. 2015 Sep;40(9):878-83. doi: 10.3109/02713683.2014.967871. Epub 2014 Oct 13. PMID: 25310688 </br>4:Effect of diquafosol tetrasodium eye drop for persistent dry eye after laser in situ keratomileusis. Mori Y, Nejima R, Masuda A, Maruyama Y, Minami K, Miyata K, Amano S.Cornea. 2014 Jul;33(7):659-62. doi: 10.1097/ICO.0000000000000136. PMID: 24858017 </br>5:Pharmacokinetic evaluation of diquafosol tetrasodium for the treatment of Sjögren/’s syndrome. Bremond-Gignac D, Gicquel JJ, Chiambaretta F.Expert Opin Drug Metab Toxicol. 2014 Jun;10(6):905-13. doi: 10.1517/17425255.2014.915026. Epub 2014 May 6. Review. PMID: 24797483 </br>6:Combination therapy with diquafosol tetrasodium and sodium hyaluronate in patients with dry eye after laser in situ keratomileusis. Toda I, Ide T, Fukumoto T, Ichihashi Y, Tsubota K.Am J Ophthalmol. 2014 Mar;157(3):616-22.e1. doi: 10.1016/j.ajo.2013.11.017. Epub 2013 Nov 27. PMID: 24528935 </br>7:Effects of diquafosol tetrasodium administration on visual function in short break-up time dry eye. Kaido M, Uchino M, Kojima T, Dogru M, Tsubota K.J Ocul Pharmacol Ther. 2013 Jul-Aug;29(6):595-603. doi: 10.1089/jop.2012.0246. Epub 2013 Mar 28. PMID: 23537148 </br>8:Clinical evaluation of the additive effect of diquafosol tetrasodium on sodium hyaluronate monotherapy in patients with dry eye syndrome: a prospective, randomized, multicenter study. Kamiya K, Nakanishi M, Ishii R, Kobashi H, Igarashi A, Sato N, Shimizu K.Eye (Lond). 2012 Oct;26(10):1363-8. doi: 10.1038/eye.2012.166. Epub 2012 Aug 10. PMID: 22878452 Free PMC Article</br>9:Double-masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eye. Tauber J, Davitt WF, Bokosky JE, Nichols KK, Yerxa BR, Schaberg AE, LaVange LM, Mills-Wilson MC, Kellerman DJ.Cornea. 2004 Nov;23(8):784-92. Erratum in: Cornea. 2007 May;26(4):514. PMID: 15502479 </br>10:Diquafosol tetrasodium. Inspire/Allergan/Santen. Fischbarg J.Curr Opin Investig Drugs. 2003 Nov;4(11):1377-83. Review. PMID: 14758778 |
