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211427-08-6-Diquafosol Tetrasodium Diquafosol Tetrasodium

Diquafosol Tetrasodium

For research use only. Not for therapeutic Use.

  • CAT Number: M017323
  • CAS Number: 211427-08-6
  • Molecular Formula: C18H22N4Na4O23P4
  • Molecular Weight: 878.233
  • Purity: ≥95%
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Related Small Molecules: Carbamic acid, acetyl-, 1,1-dimethylethyl ester (9CI)     N-[(Benzyloxy)carbonyl]glycylglycine     H-ALA-ONB HBR    

Catalog Number M017323
CAS Number 211427-08-6
Synonyms

INS 365;D03864;Diquafosol sodium;Diquafosol sodium (jan);Diquafosol tetrasodium;Diquafosol tetrasodium (usan)

Molecular Formula C18H22N4Na4O23P4
Purity ≥95%
Storage -20°C
InChIKey OWTGMPPCCUSXIP-FNXFGIETSA-J
SMILES C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])OP(=O)([O-])OCC3C(C(C(O3)N4C=CC(=O)NC4=O)O)O)O)O.[Na+].[Na+].[Na+].[Na+]
Reference

1: Cui L, Li Y, Lee HS, Yang JM, Choi W, Yoon KC. Effect of diquafosol
tetrasodium 3% on the conjunctival surface and clinical findings after cataract
surgery in patients with dry eye. Int Ophthalmol. 2017 Aug 18. doi:
10.1007/s10792-017-0693-1. [Epub ahead of print] PubMed PMID: 28822028.
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2: Lee JH, Lee JS, Kim S, Lee JE. Comparison of cytotoxicities and wound healing
effects of diquafosol tetrasodium and hyaluronic acid on human corneal epithelial
cells. Korean J Physiol Pharmacol. 2017 Mar;21(2):189-195. doi:
10.4196/kjpp.2017.21.2.189. Epub 2017 Feb 21. PubMed PMID: 28280412; PubMed
Central PMCID: PMC5343052.
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3: Baek J, Doh SH, Chung SK. The Effect of Topical Diquafosol Tetrasodium 3% on
Dry Eye After Cataract Surgery. Curr Eye Res. 2016 Oct;41(10):1281-1285. Epub
2016 Apr 6. PubMed PMID: 27049809.

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4: Shigeyasu C, Hirano S, Akune Y, Yamada M. Diquafosol Tetrasodium Increases the
Concentration of Mucin-like Substances in Tears of Healthy Human Subjects. Curr
Eye Res. 2015 Sep;40(9):878-83. doi: 10.3109/02713683.2014.967871. Epub 2014 Oct
13. PubMed PMID: 25310688.
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5: Mori Y, Nejima R, Masuda A, Maruyama Y, Minami K, Miyata K, Amano S. Effect of
diquafosol tetrasodium eye drop for persistent dry eye after laser in situ
keratomileusis. Cornea. 2014 Jul;33(7):659-62. doi: 10.1097/ICO.0000000000000136.
PubMed PMID: 24858017.
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6: Bremond-Gignac D, Gicquel JJ, Chiambaretta F. Pharmacokinetic evaluation of
diquafosol tetrasodium for the treatment of Sj&#246;gren/’s syndrome. Expert Opin Drug
Metab Toxicol. 2014 Jun;10(6):905-13. doi: 10.1517/17425255.2014.915026. Epub
2014 May 6. Review. PubMed PMID: 24797483.

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7: Toda I, Ide T, Fukumoto T, Ichihashi Y, Tsubota K. Combination therapy with
diquafosol tetrasodium and sodium hyaluronate in patients with dry eye after
laser in situ keratomileusis. Am J Ophthalmol. 2014 Mar;157(3):616-22.e1. doi:
10.1016/j.ajo.2013.11.017. Epub 2013 Nov 27. PubMed PMID: 24528935.

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