Distigmine Bromide

• CAT Number: R014940
• CAS Number: 15876-67-2
• Molecular Formula: C22H32Br2N4O4
• Molecular Weight: 576.33
• Purity: ≥95%
• Synonyms: Hexamethylenebis[methylcarbamate] 3-Hydroxy-1-methylpyridinium Bromide; 3,3’-[1,6-Hexanediylbis[(methylimino)carbonyl]oxy]bis[1-methyl-pyridinium Dibromide; BC 51; Distigmine Dibromide; Hexamarium; N,N’-Hexamethylenebis(3-N-methylcarbamoxy-1-methylpy
• Target: Cholinesterase (ChE)
• Storage: -20°C
• IUPAC Name: (1-methylpyridin-1-ium-3-yl) N-methyl-N-[6-[methyl-(1-methylpyridin-1-ium-3-yl)oxycarbonylamino]hexyl]carbamate;dibromide
• InChI: InChI=1S/C22H32N4O4.2BrH/c1-23-13-9-11-19(17-23)29-21(27)25(3)15-7-5-6-8-16-26(4)22(28)30-20-12-10-14-24(2)18-20;;/h9-14,17-18H,5-8,15-16H2,1-4H3;2*1H/q+2;;/p-2
• InChIKey: GJHSNEVFXQVOHR-UHFFFAOYSA-L
• SMILES: C[N+]1=CC=CC(=C1)OC(=O)N(C)CCCCCCN(C)C(=O)OC2=C[N+](=CC=C2)C.[Br-].[Br-]

Distigmine Bromide (CAT: R014940) is a medication used to treat conditions characterized by muscle weakness or dysfunction, such as myasthenia gravis. It functions as a reversible acetylcholinesterase inhibitor, preventing the breakdown of acetylcholine, a neurotransmitter crucial for muscle function. By increasing the availability of acetylcholine at the neuromuscular junction, Distigmine Bromide helps improve muscle strength and contraction.

Reference

1.Kobayashi, Kazuki, et al. "Bowel obstruction-induced cholinergic crisis with progressive respiratory failure following distigmine bromide treatment." Chudoku kenkyu: Chudoku Kenkyukai jun kikanshi= The Japanese journal of toxicology 29.1 (2016): 26-29.
2.Mohamed, Gehad Genidy, Mahmoud Sabry Rizk, and Eman Yousry Zaky Frag. "Spectrophotometric determination of distigmine bromide, cyclopentolate HCl, diaveridine HCl and tetrahydrozoline HCl via charge transfer complex formation with TCNQ and TCNE reagents." Iranian journal of pharmaceutical research: IJPR 14.3 (2015): 701.
3.Izumi, K., et al. "Effects of bethanechol chloride and distigmine bromide on postvoiding residual volume in patients with underactive bladder." Minerva urologica e nefrologica= The Italian journal of urology and nephrology 66.4 (2014): 241-247.