For research use only. Not for therapeutic Use.
Disulfiram(Cat No.:A000724)is an oral medication used primarily to treat chronic alcoholism by inhibiting aldehyde dehydrogenase, an enzyme involved in alcohol metabolism. When alcohol is consumed, disulfiram causes the accumulation of acetaldehyde, leading to unpleasant effects such as nausea, headache, and flushing, thereby deterring further drinking. Beyond its use in alcohol aversion therapy, disulfiram has shown potential in cancer research due to its ability to inhibit proteasome activity and disrupt cellular metal homeostasis. It has also been investigated for its antibacterial and antiviral properties, broadening its therapeutic applications.
CAS Number | 97-77-8 |
Synonyms | Tetraethylthiuram disulfide; 97-77-8; Antabuse; Alcophobin; Antabus |
Molecular Formula | C₁₀H₂₀N₂S₄ |
Purity | ≥95% |
Target | Immunology/Inflammation |
Solubility | >12mg/mL in DMSO |
Storage | -20°C |
IUPAC Name | diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate |
InChI | InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3 |
InChIKey | AUZONCFQVSMFAP-UHFFFAOYSA-N |
SMILES | CCN(CC)C(=S)SSC(=S)N(CC)CC |
Reference | 1: Wang NN, Wang LH, Li Y, Fu SY, Xue X, Jia LN, Yuan XZ, Wang YT, Tang X, Yang <br> <br> <br> <br> 6: Viola-Rhenals M, Patel KR, Jaimes-Santamaria L, Wu G, Liu J, Dou QP. Recent <br> <br> 9: Hasinoff BB, Patel D. Disulfiram is a slow-binding partial noncompetitive <br> |
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