Dizocilpine free base

• CAT Number: I006503
• CAS Number: 77086-21-6 (free base)
• Molecular Formula: C16H15N
• Molecular Weight: 221.30
• Purity: ≥95%
• Synonyms: Dizocilpine; MK801; MK 801; MK-801; MK 801 Maleate;(5S)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene
• Target: Membrane Transporter/Ion Channel
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term or -20 °C for long term
• IUPAC Name: (1S,9R)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2,4,6,10,12,14-hexaene
• InChI: InChI=1S/C16H15N/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16/h2-9,15,17H,10H2,1H3/t15-,16+/m1/s1
• InChIKey: LBOJYSIDWZQNJS-CVEARBPZSA-N
• SMILES: C[C@@]12C3=CC=CC=C3C[C@@H](N1)C4=CC=CC=C24

Dizocilpine free base（Cat No.:I006503）, is a potent non-competitive antagonist of the NMDA (N-Methyl-D-Aspartate) receptor, which is involved in synaptic plasticity, memory, and learning. By blocking the NMDA receptor, dizocilpine inhibits excitatory neurotransmission, leading to effects such as neuroprotective properties, as well as behavioral changes. It is commonly used in research to study neurodegenerative diseases, ischemia, and psychiatric disorders, including schizophrenia. Although it has significant research value, dizocilpine is not approved for clinical use due to its neurotoxic effects at high doses.