For research use only. Not for therapeutic Use.
Dizocilpine is a potent and selective non-competitive NMDA receptor antagonist. Dizocilpine acts as an open channel blocker of the NMDA receptor operated ion channel. It is a drug implicated in central nervous system with anesthetic and anticonvulsant effect.
| Catalog Number | I006503 |
| CAS Number | 77086-21-6 (free base) |
| Synonyms | Dizocilpine; MK801; MK 801; MK-801; MK 801 Maleate;(5S)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene |
| Molecular Formula | C16H15N |
| Purity | ≥95% |
| Target | Membrane Transporter/Ion Channel |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| SMILES | C[C@]1(N2)C3=CC=CC=C3CC2C4=CC=CC=C14 |
| Reference | </br>1:Khan N, Saad A, Nurulain SM, Darras FH, Decker M, Sadek B. The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats. Behav Brain Res. 2015 Oct 17;297:155-164. doi: 10.1016/j.bbr.2015.10.022. [Epub ahead of print] PubMed PMID: 26467607. |
