Dizocilpine maleate

• CAT Number: I006504
• CAS Number: 77086-22-7 (maleate)
• Molecular Formula: C20H19NO4
• Molecular Weight: 337.38
• Purity: ≥95%
• Synonyms: MK-801; MK 801; MK801; MK-801 maleate; Dizocilpine maleate.;5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene maleate
• Target: NMDA antagonist
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term or -20 °C for long term
• IUPAC Name: (Z)-but-2-enedioic acid;(1S,9R)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2,4,6,10,12,14-hexaene
• InChI: InChI=1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChIKey: QLTXKCWMEZIHBJ-BTJKTKAUSA-N
• SMILES: C[C@@]12C3=CC=CC=C3C[C@@H](N1)C4=CC=CC=C24.C(=C\C(=O)O)\C(=O)O

Dizocilpine Maleate (MK-801)(CAT: I006504) is a potent and non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, widely used in neuropharmacological and neurological research. By blocking the ion channel of NMDA receptors, it inhibits excitatory neurotransmission mediated by glutamate, a critical pathway in synaptic plasticity and neurodegeneration. Dizocilpine Maleate is instrumental in studying conditions such as epilepsy, stroke, neurotoxicity, and psychiatric disorders, including schizophrenia. Its high potency and specificity make it suitable for both in vitro and in vivo applications. With superior purity and stability, Dizocilpine Maleate supports investigations into NMDA receptor function and the development of novel neuroprotective therapies.