DKFZ-748

For research use only. Not for therapeutic Use.

  • CAT Number: I042605
  • CAS Number: 2490709-68-5
  • Molecular Formula: C18H23N3O3
  • Molecular Weight: 329.39
  • Purity: ≥95%
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DKFZ-748 is a selective HDAC10 inhibitor (pIC50=7.66), and shows anti-tumor activity[1].
DKFZ-748 shows dose-dependent growth inhibition of HeLa cells in a polyamine-limiting in vitro tumor model[1].
DKFZ-748 (1-100 μM; 72 h) induces HDAC acetylation of BE(2)-C cells[1].
DKFZ 748 shows significant accumulation of N8 acetyl- and N1,8-diacetylspermidine in a dose-dependent manner[1].


Catalog Number I042605
CAS Number 2490709-68-5
Synonyms

N-[2-[[4-(hydroxyamino)-4-oxobutyl]-methylamino]ethyl]naphthalene-1-carboxamide

Molecular Formula C18H23N3O3
Purity ≥95%
InChI InChI=1S/C18H23N3O3/c1-21(12-5-10-17(22)20-24)13-11-19-18(23)16-9-4-7-14-6-2-3-8-15(14)16/h2-4,6-9,24H,5,10-13H2,1H3,(H,19,23)(H,20,22)
InChIKey KLGDKBPAEMOECW-UHFFFAOYSA-N
SMILES CN(CCCC(=O)NO)CCNC(=O)C1=CC=CC2=CC=CC=C21
Reference

[1]. Steimbach RR, et al. Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J Am Chem Soc. 2022 Oct 19;144(41):18861-18875.
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