D,L-erythro-PDMP hydrochloride

• CAT Number: I041324
• CAS Number: 80943-40-4
• Molecular Formula: C23H39ClN2O3
• Molecular Weight: 427.02
• Purity: ≥95%
• Synonyms: N-[(1S,2R)-1-hydroxy-3-morpholin-4-yl-1-phenylpropan-2-yl]decanamide;hydrochloride
• InChI: InChI=1S/C23H38N2O3.ClH/c1-2-3-4-5-6-7-11-14-22(26)24-21(19-25-15-17-28-18-16-25)23(27)20-12-9-8-10-13-20;/h8-10,12-13,21,23,27H,2-7,11,14-19H2,1H3,(H,24,26);1H/t21-,23+;/m1./s1
• InChIKey: HVJHJOYQTSEKPK-QRIJJCFISA-N
• SMILES: CCCCCCCCCC(=O)NC(CN1CCOCC1)C(C2=CC=CC=C2)O.Cl

D,L-erythro-PDMP hydrochloride is an erythro isomer of PDMP. D,L-erythro-PDMP hydrochloride causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase[1][2].
D,L-erythro-PDMP hydrochloride (0, 12, 25, 50 μM; 0, 4, 7, 10 days) shows an inhibitory effect on cell growth of rabbit skin fibroblasts[1].
D,L-erythro PDMP hydrochloride (50 μM; 3 days) has cytotoxic of rabbit skin fibroblasts on cell morphology[1].
D,L-erythro-PDMP hydrochloride (40 μM; 24 h; MDCK cells) induces a marked increase in glucosyltransferase specific activity: 14.6 nmol/h per mg protein[2].
D,L-erythro-PDMP hydrochloride (40 μM; 6 h) protects the cells against loss of synthase in cells exposed to cycloheximide[2].

Reference

[1]. Uemura K, et al. Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblasts. J Biochem. 1990 Oct;108(4):525-30.
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[2]. Abe A, et al. Induction of glucosylceramide synthase by synthase inhibitors and ceramide. Biochim Biophys Acta. 1996 Feb 16;1299(3):333-41.
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