DL-GOITRIN

• CAT Number: M061256
• CAS Number: 13190-34-6
• Molecular Formula: C5H7NOS
• Molecular Weight: 129.177
• Purity: ≥95%
• Target: Influenza Virus
• Storage: Store at RT
• IUPAC Name: 5-ethenyl-1,3-oxazolidine-2-thione
• InChI: InChI=1S/C5H7NOS/c1-2-4-3-6-5(8)7-4/h2,4H,1,3H2,(H,6,8)
• InChIKey: UZQVYLOFLQICCT-UHFFFAOYSA-N
• SMILES: C=CC1CNC(=S)O1

DL-GOITRIN (CAS 13190-34-6) is a goitrogen and antithyroid compound that has been found in plants of the Brassica family.Dietary administration of (±)-goitrin (0.06-0.18% w/w) increases thyroid weight and decreases thyroid radioactive iodine uptake in rats fed a low-iodine diet. It also increases thyroid weight in chicks in a dose-dependent manner. (±)-Goitrin inhibits norepinephrine formation by bovine dopamine-β-hydroxylase in vitro when used at a concentration of 0.2 mM.

Reference

1.Faiman, C., R. J. Ryan, and H. J. Eichel. "Effect of goitrin analogues and related compounds on the rat thyroid gland." Endocrinology 81.1 (1967): 88-92.
2.Akiba, Yukio, and Tatsuro Matsumoto. "Antithyroid activity of goitrin in chicks." Poultry science 55.2 (1976): 716-719.
3. Zenker, N., Hubbard, L.S., and Wright, J. Inhibition of dopamine β-<wbr style="box-sizing: border-box;" />hydroxylase by goitrin, a natural antithyroid compound. J. Nat. Prod.51(5), 862-865 (1988).