For research use only. Not for therapeutic Use.
Hydrogen sulphide (H<sub>2</sub>S), a naturally occurring gasotransmitter, is a potent vasodilator and pro-<wbr></wbr>inflammatory mediator. DL-<wbr></wbr>Propargyl glycine (PAG) is an irreversible inhibitor of the H<sub>2</sub>S synthesizing enzyme cystathionine-<wbr></wbr>γ-<wbr></wbr>lyase (CSE). PAG blocks H<sub>2</sub>S synthesis activity in rat liver preparations with an IC<sub>50</sub> value of 55 µM and abolishes the rise in plasma H<sub>2</sub>S in anaesthetized rats induced with hemorrhagic shock. At concentrations ranging from 25-<wbr></wbr>100 mg/kg, PAG can reduce H<sub>2</sub>S-<wbr></wbr>associated inflammation in rodent models of pancreatitis, oedema, and endotoxemia.
| Catalog Number | M131451 |
| CAS Number | 16900-57-5 |
| Synonyms | 2-Amino-4-pentynoic acid hydrochloride |
| Molecular Formula | C5H8ClNO2 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | 2-aminopent-4-ynoic acid;hydrochloride |
| InChI | InChI=1S/C5H7NO2.ClH/c1-2-3-4(6)5(7)8;/h1,4H,3,6H2,(H,7,8);1H |
| InChIKey | UAMBUICGODABQY-UHFFFAOYSA-N |
| SMILES | C#CCC(C(=O)O)N.Cl |
