For research use only. Not for therapeutic Use.
DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is an orally active HDAC inhibitor and metabolite of sulforaphane (HY-13755) with longer half-life and better blood-brain barrier permeability. DL-Sulforaphane N-acetyl-L-cysteine activates autophagy-mediated downregulation of α-tubulin expression through the ERK pathway and can be used in cancer research[1][2].
SFN-NAC (24 h) decreases cell viability, with IC50 values of 60.08 μM for HA, 35.20 μM for U87MG, 39.11 μM for U373MG, and 36.20 μM for the U87/TR cells[1].
SFN-NAC (10 μmol; 6 h; Oral gavage; single dose) significantly inhibits HDAC activity in mouse colon mucosa[2].
| Catalog Number | R005424 |
| CAS Number | 334829-66-2 |
| Synonyms | (2R)-2-acetamido-3-(4-methylsulfinylbutylcarbamothioylsulfanyl)propanoic acid |
| Molecular Formula | C11H20N2O4S3 |
| Purity | ≥95% |
| InChI | InChI=1S/C11H20N2O4S3/c1-8(14)13-9(10(15)16)7-19-11(18)12-5-3-4-6-20(2)17/h9H,3-7H2,1-2H3,(H,12,18)(H,13,14)(H,15,16)/t9-,20?/m0/s1 |
| InChIKey | IIHBKTCHILXGOT-KMYGYIBBSA-N |
| SMILES | CC(=O)NC(CSC(=S)NCCCCS(=O)C)C(=O)O |
| Reference | [1]. Liu HJ, et al. Sulforaphane-N-Acetyl-Cysteine Induces Autophagy Through Activation of ERK1/2 in U87MG and U373MG Cells. Cell Physiol Biochem. 2018;51(2):528-542. [2]. Dashwood R H, et al. Dietary histone deacetylase inhibitors: from cells to mice to man[C]//Seminars in cancer biology. Academic Press, 2007, 17(5): 363-369. |
