D[LEU4,LYS8]-VP TFA

For research use only. Not for therapeutic Use.

  • CAT Number: I045737
  • Molecular Formula: C49H68F3N11O13S2
  • Molecular Weight: 1140.25
  • Purity: ≥95%
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D[LEU4,LYS8]-VP TFA is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. D[LEU4,LYS8]-VP TFA has weak antidiuretic, vasopressor, and in vitro oxytocic activities[1][2].


Catalog Number I045737
Molecular Formula C49H68F3N11O13S2
Purity ≥95%
Reference

[1]. Ana P, et, al. Pharmacological and physiological characterization of d[Leu4, Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology. 2007 Sep; 148(9): 4136-46.
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[2]. Ana P, et, al. Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8. J Med Chem. 2007 Feb 22; 50(4): 835-47.
 [Content Brief]

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