For research use only. Not for therapeutic Use.
DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery[1].
The structure of DLinDMA can be divided into three main regions: the hydrocarbon chains, the linker and the headgroup[1].
DLinDMA has virtually indistinguishable blood pharmacokinetic profiles in mice[1].
| Catalog Number | I019811 |
| CAS Number | 871258-12-7 |
| Synonyms | N,N-dimethyl-2,3-bis[(9Z,12Z)-octadeca-9,12-dienoxy]propan-1-amine |
| Molecular Formula | C41H77NO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C41H77NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-43-40-41(39-42(3)4)44-38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h13-16,19-22,41H,5-12,17-18,23-40H2,1-4H3/b15-13-,16-14-,21-19-,22-20- |
| InChIKey | NFQBIAXADRDUGK-KWXKLSQISA-N |
| SMILES | CCCCCC=CCC=CCCCCCCCCOCC(CN(C)C)OCCCCCCCCC=CCC=CCCCCC |
| Reference | [1]. Semple SC, et al. Rational design of cationic lipids for siRNA delivery. Nat Biotechnol. 2010 Feb;28(2):172-6. |
