DM3

• CAT Number: I017767
• CAS Number: 796073-54-6
• Molecular Formula: C₃₇H₅₂ClN₃O₁₀S
• Molecular Weight: 766.34
• Purity: ≥95%
• IUPAC Name: [(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl(4-sulfanylpentanoyl)amino]propanoate
• InChI: InChI=1S/C37H52ClN3O10S/c1-20-11-10-12-28(48-9)37(46)19-27(49-35(45)39-37)22(3)33-36(5,51-33)29(50-34(44)23(4)40(6)30(42)14-13-21(2)52)18-31(43)41(7)25-16-24(15-20)17-26(47-8)32(25)38/h10-12,16-17,21-23,27-29,33,46,52H,13-15,18-19H2,1-9H3,(H,39,45)/b12-10+,20-11+/t21?,22-,23+,27+,28-,29+,33+,36+,37+/m1/s1
• InChIKey: LJFFDOBFKICLHN-IXWHRVGISA-N
• SMILES: C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCC(C)S)C)C)OC)(NC(=O)O2)O

DM3 (Cat.No:I017767) is a potent cytotoxic agent used in targeted cancer therapies. It consists of a maytansinoid derivative conjugated to an antibody or antibody-drug conjugate (ADC). DM3 binds to specific cancer cell targets, delivering the cytotoxic payload to destroy the cancer cells. 

Reference

[1]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).