DM489

• CAT Number: I026367
• Molecular Formula: C15H13NO2
• Molecular Weight: 239.27
• Purity: 98%
• Synonyms: DM489; DM 489; DM-489
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (E)-3-(furan-2-yl)-1-(indolin-1-yl)prop-2-en-1-one
• InChI: InChI=1S/C15H13NO2/c17-15(8-7-13-5-3-11-18-13)16-10-9-12-4-1-2-6-14(12)16/h1-8,11H,9-10H2/b8-7+
• InChIKey: XFJDULHCELCQOW-BQYQJAHWSA-N
• SMILES: O=C(N1CCC2=C1C=CC=C2)/C=C/C3=CC=CO3

DM489(CAT: I026367) is a novel positive allosteric modulator (PAM) of α7 nicotinic acetylcholine receptors (α7 nAChRs), extensively studied for its therapeutic potential in neuropathic pain management. By enhancing the activity of α7 nAChRs, DM489 modulates neuronal signaling, reducing hyperexcitability and inflammation associated with neuropathic pain. It has demonstrated efficacy in alleviating streptozotocin (STZ)-induced diabetic neuropathy and chemotherapy-induced peripheral neuropathy in preclinical models. This compound is valuable for exploring the mechanisms of α7 nAChR modulation and its implications for treating pain disorders. DM489 offers a promising approach for addressing neuropathic pain, with potential applications in broader neurological and inflammatory conditions.