For research use only. Not for therapeutic Use.
DMH1 (Cat No.: I000766) is a highly selective inhibitor of BMP (Bone Morphogenetic Protein) receptors. It effectively inhibits ALK2 with an IC50 of 107.9 nM while displaying no inhibitory effects on AMPK, ALK5, KDR (VEGFR-2), or PDGFR. Additionally, DMH1 is known to inhibit autophagy, making it a valuable tool in research related to BMP signaling and autophagy modulation. Should you require further information or have inquiries, please do not hesitate to contact us. Our team is committed to providing a prompt response within 24 hours.
| Catalog Number | I000766 |
| CAS Number | 1206711-16-1 |
| Molecular Formula | C₂₄H₂₀N₄O |
| Purity | ≥95% |
| Target | TGF-βR1(ALK5) |
| Solubility | DMSO: ≤ 11.5 mg/mL |
| Storage | 2-8°C |
| IC50 | 27/107.9/<5 nM(ALK1/2/3) |
| IUPAC Name | 4-[6-(4-propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline |
| InChI | InChI=1S/C24H20N4O/c1-16(2)29-19-9-7-17(8-10-19)18-13-26-24-22(14-27-28(24)15-18)20-11-12-25-23-6-4-3-5-21(20)23/h3-16H,1-2H3 |
| InChIKey | JMIFGARJSWXZSH-UHFFFAOYSA-N |
| SMILES | CC(C)OC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=CC=NC5=CC=CC=C45)N=C2 |
