For research use only. Not for therapeutic Use.
DMNB-caged-Serine is a photocaged amino acid. DMNB-caged-Serine can be used as a catalytic residue, hydrogen bonding partner or site of post-translational modification. DMNB-caged-Serine can be used for the control of protein phosphorylation[1].
When substituted at phosphoserine sites that control nuclear export of Pho4, DMNB-caged-Serine blocks phosphorylation and subsequent export by the receptor Msn5[1].
| Catalog Number | I015229 |
| CAS Number | 780009-55-4 |
| Synonyms | (2S)-2-amino-3-[(4,5-dimethoxy-2-nitrophenyl)methoxy]propanoic acid |
| Molecular Formula | C12H16N2O7 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H16N2O7/c1-19-10-3-7(5-21-6-8(13)12(15)16)9(14(17)18)4-11(10)20-2/h3-4,8H,5-6,13H2,1-2H3,(H,15,16)/t8-/m0/s1 |
| InChIKey | HYSPNOMZFGNKBR-QMMMGPOBSA-N |
| SMILES | COC1=C(C=C(C(=C1)COCC(C(=O)O)N)[N+](=O)[O-])OC |
| Reference | [1]. Edward A Lemke, et al. Control of protein phosphorylation with a genetically encoded photocaged amino acid. Nat Chem Biol. 2007 Dec;3(12):769-72. [2]. Qing Shao, et al. Photoactive molecules for applications in molecular imaging and cell biology. Chem Soc Rev. 2010 Aug;39(8):2835-46. [3]. Brieke C, et al. Light-controlled tools. Angew Chem Int Ed Engl. 2012 Aug 20;51(34):8446-76. |
