For research use only. Not for therapeutic Use.
DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer[1][2].
DMP-543 enhances [3H]ACh release from rat brain slices, with an EC50 of 700 nM[2].
| Catalog Number | M035764 |
| CAS Number | 160588-45-4 |
| Synonyms | 10,10-bis[(2-fluoropyridin-4-yl)methyl]anthracen-9-one |
| Molecular Formula | C26H18F2N2O |
| Purity | ≥95% |
| InChI | InChI=1S/C26H18F2N2O/c27-23-13-17(9-11-29-23)15-26(16-18-10-12-30-24(28)14-18)21-7-3-1-5-19(21)25(31)20-6-2-4-8-22(20)26/h1-14H,15-16H2 |
| InChIKey | MUJBUUDUXGDXLW-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2(CC4=CC(=NC=C4)F)CC5=CC(=NC=C5)F |
| Reference | [1]. Ipavec V, et al. KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus. Pharmacol Res. 2011 Oct;64(4):397-409. [2]. Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30. |
