For research use only. Not for therapeutic Use.
DMP 777 (Cat.No:I001998) is a chemical compound with potential therapeutic applications. It acts as a selective modulator of sigma receptors, which are involved in various physiological processes. DMP 777 has been studied for its potential in neuroprotection and as an antidepressant. Further research is underway to explore its efficacy and safety profiles.
| Catalog Number | I001998 |
| CAS Number | 157341-41-8 |
| Synonyms | (2S)-N-[(1R)-1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-(4-methylpiperazine-1-carbonyl)phenoxy]-4-oxoazetidine-1-carboxamide |
| Molecular Formula | C31H40N4O6 |
| Purity | ≥95% |
| Target | Elastase |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | (2S)-N-[(1R)-1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-(4-methylpiperazine-1-carbonyl)phenoxy]-4-oxoazetidine-1-carboxamide |
| InChI | InChI=1S/C31H40N4O6/c1-5-8-24(22-11-14-25-26(19-22)40-20-39-25)32-30(38)35-28(37)31(6-2,7-3)29(35)41-23-12-9-21(10-13-23)27(36)34-17-15-33(4)16-18-34/h9-14,19,24,29H,5-8,15-18,20H2,1-4H3,(H,32,38)/t24-,29+/m1/s1 |
| InChIKey | ZSDCIRYNTCVTMF-GIGWZHCTSA-N |
| SMILES | CCC[C@H](C1=CC2=C(C=C1)OCO2)NC(=O)N3[C@H](C(C3=O)(CC)CC)OC4=CC=C(C=C4)C(=O)N5CCN(CC5)C |
| Reference | </br>1:Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777. Ogawa M, Nomura S, Car BD, Goldenring JR.Dig Dis Sci. 2006 Mar;51(3):431-9. PMID: 16614949 </br>2:Isolation and identification of a degradation product in a capsule formulation containing the elastase inhibitor, DMP 777. Buckley D, Haas MJ, Scholz TH, Sigvardson KW.J Pharm Biomed Anal. 2001 Feb;24(4):651-7. PMID: 11272322 </br>3:Degradation kinetics of DMP 777, an elastase inhibitor. Raghavan KS, Gray DB, Scholz TH, Nemeth GA, Hussain MA.Pharm Res. 1996 Dec;13(12):1815-20. PMID: 8987077 |
