DNAC-1

• CAT Number: I026395
• CAS Number: 1006021-30-2
• Molecular Formula: C11H9BrN2S2
• Molecular Weight: 313.23
• Purity: 98%
• Synonyms: DNAC-1; DNAC 1; DNAC1
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 3-(5-Bromo-3,4-dimethyl-thieno[2,3-b]thiophen-2-yl)-1H-pyrazole
• InChI: InChI=1S/C11H9BrN2S2/c1-5-8-6(2)10(12)16-11(8)15-9(5)7-3-4-13-14-7/h3-4H,1-2H3,(H,13,14)
• InChIKey: MUNXAASMRMRSCE-UHFFFAOYSA-N
• SMILES: CC1=C(Br)SC2=C1C(C)=C(C3=NNC=C3)S2

DNAC-1 is a potentiator of β-lactam activity against Gram positive and Gram negative pathogens.

Reference

1: Nair DR, Monteiro JM, Memmi G, Thanassi J, Pucci M, Schwartzman J, Pinho MG, Cheung AL. Characterization of a novel small molecule that potentiates β-lactam activity against gram-positive and gram-negative pathogens. Antimicrob Agents Chemother. 2015 Apr;59(4):1876-85. doi: 10.1128/AAC.04164-14. Epub 2015 Jan 12. PubMed PMID: 25583731; PubMed Central PMCID: PMC4356822.
2: Galletto R, Bujalowski W. The E. coli replication factor DnaC protein exists in two conformations with different nucleotide binding capabilities. I. Determination of the binding mechanism using ATP and ADP fluorescent analogues. Biochemistry. 2002 Jul 16;41(28):8907-20. PubMed PMID: 12102633.