DNP-NH-PEG2-C2-acid

• CAT Number: I016993
• CAS Number: 1353011-89-8
• Molecular Formula: C13H17N3O8
• Molecular Weight: 343.29
• Purity: ≥95%
• Synonyms: 3-[2-[2-(2,4-dinitroanilino)ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C13H17N3O8/c17-13(18)3-5-23-7-8-24-6-4-14-11-2-1-10(15(19)20)9-12(11)16(21)22/h1-2,9,14H,3-8H2,(H,17,18)
• InChIKey: ZZALENBFHFRJPM-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])NCCOCCOCCC(=O)O

DNP-NH-PEG2-C2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
 [Content Brief]