Dobutamine free base

For research use only. Not for therapeutic Use.

  • CAT Number: I026416
  • CAS Number: 34368-04-2
  • Molecular Formula: C18H23NO3
  • Molecular Weight: 301.39
  • Purity: 98%
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Dobutamine Free Base is a catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.


Catalog Number I026416
CAS Number 34368-04-2
Synonyms

Dobutamine Free Base; LY81929; LY-81929; LY 81929

Molecular Formula C18H23NO3
Purity 98%
Target Neuronal Signaling
Solubility To be determined
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 1,2-Benzenediol, 4-(2-((3-(4-hydroxyphenyl)-1-methylpropyl)amino)ethyl)-, (+-)-
InChI InChI=1S/C18H23NO3/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15/h4-9,12-13,19-22H,2-3,10-11H2,1H3
InChIKey JRWZLRBJNMZMFE-UHFFFAOYSA-N
SMILES OC1=CC=C(CCNC(C)CCC2=CC=C(O)C=C2)C=C1O
Reference

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3: Follath F, Cleland JG, Just H, Papp JG, Scholz H, Peuhkurinen K, Harjola VP, Mitrovic V, Abdalla M, Sandell EP, Lehtonen L; Steering Committee and Investigators of the Levosimendan Infusion versus Dobutamine (LIDO) Study. Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial. Lancet. 2002 Jul 20;360(9328):196-202. doi: 10.1016/s0140-6736(02)09455-2. PMID: 12133653.
4: O’Connor CM, Gattis WA, Uretsky BF, Adams KF Jr, McNulty SE, Grossman SH, McKenna WJ, Zannad F, Swedberg K, Gheorghiade M, Califf RM. Continuous intravenous dobutamine is associated with an increased risk of death in patients with advanced heart failure: insights from the Flolan International Randomized Survival Trial (FIRST). Am Heart J. 1999 Jul;138(1 Pt 1):78-86. doi: 10.1016/s0002-8703(99)70250-4. PMID: 10385768.
5: Mahoney L, Shah G, Crook D, Rojas-Anaya H, Rabe H. A Literature Review of the Pharmacokinetics and Pharmacodynamics of Dobutamine in Neonates. Pediatr Cardiol. 2016 Jan;37(1):14-23. doi: 10.1007/s00246-015-1263-9. Epub 2015 Sep 7. Erratum in: Pediatr Cardiol. 2016 Dec 1;: PMID: 26346024.
6: Mielgo V, Valls i Soler A, Rey-Santano C. Dobutamine in paediatric population: a systematic review in juvenile animal models. PLoS One. 2014 Apr 22;9(4):e95644. doi: 10.1371/journal.pone.0095644. PMID: 24755688; PMCID: PMC3995779.
7: Al Madfai F, Valah B, Zaidi STR, Wanandy T, Ming LC, Peterson GM, Patel RP. Stability of dobutamine in continuous ambulatory delivery devices. J Clin Pharm Ther. 2018 Aug;43(4):530-535. doi: 10.1111/jcpt.12674. Epub 2018 Mar 2. PMID: 29500838.
8: Madias JE. Pathophysiological insights from dobutamine-induced Takotsubo syndrome. Anatol J Cardiol. 2018 Aug;20(2):134. doi: 10.14744/AnatolJCardiol.2018.50708. PMID: 30088490; PMCID: PMC6237951.
9: Wislicki L. [Dobutamine]. Harefuah. 1979 Dec;97(11-12):312-3. Hebrew. PMID: 16296120.
10: Kittleson MD. Dobutamine. J Am Vet Med Assoc. 1980 Oct 1;177(7):642-3. PMID: 7440359.

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