For research use only. Not for therapeutic Use.
Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects[1][2].
Docosahexaenoic acid ethyl ester (DHA-EE) (500 mg/kg; IP; once daily for 7 days) enhances 6-OHDA-induced reduction of striatal dopamine level[2].
| Catalog Number | R010691 |
| CAS Number | 81926-94-5 |
| Synonyms | ethyl (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoate |
| Molecular Formula | C24H36O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H36O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26-4-2/h5-6,8-9,11-12,14-15,17-18,20-21H,3-4,7,10,13,16,19,22-23H2,1-2H3/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20- |
| InChIKey | ITNKVODZACVXDS-YNUSHXQLSA-N |
| SMILES | CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)OCC |
| Reference | [1]. Dahms I, et al. Safety of docosahexaenoic acid (DHA) administered as DHA ethyl ester in a 9-month toxicity study in dogs. Food Chem Toxicol. 2016;92:50-57. [2]. Kabuto H, et al. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Neurochem Res. 2009;34(7):1299-1303. |
