Dodecylphosphocholine

For research use only. Not for therapeutic Use.

  • CAT Number: I026429
  • CAS Number: 29557-51-5
  • Molecular Formula: C17H38NO4P
  • Molecular Weight: 351.47
  • Purity: ≥95%
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Dodecylphosphocholine (Cat.No:I026429) is a zwitterionic detergent commonly used in biochemical and biophysical research. It is known for its ability to solubilize membrane proteins while maintaining their native structure and functionality. Dodecylphosphocholine is widely utilized in protein purification, membrane protein characterization, and structural biology studies. Its mild properties make it suitable for various applications in the field of life sciences.


Catalog Number I026429
CAS Number 29557-51-5
Synonyms

Dodecylphosphocholine; DPC; DDPPC; n-C12PC; Foscholine-12; nC12PC; n C12PC; Foscholine12; Foscholine 12

Molecular Formula C17H38NO4P
Purity ≥95%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
IUPAC Name Dodecyl 2-(trimethylammonio)ethyl phosphate
InChI InChI=1S/C17H38NO4P/c1-5-6-7-8-9-10-11-12-13-14-16-21-23(19,20)22-17-15-18(2,3)4/h5-17H2,1-4H3
InChIKey QBHFVMDLPTZDOI-UHFFFAOYSA-N
SMILES O=P(OCCCCCCCCCCCC)([O-])OCC[N+](C)(C)C
Reference

1: Goyal S, Qin H, Lim L, Song J. Insoluble protein characterization by circular dichroism (CD) spectroscopy and nuclear magnetic resonance (NMR). Methods Mol Biol. 2015;1258:371-85. doi: 10.1007/978-1-4939-2205-5_21. Review. PubMed PMID: 25447876.
2: Stephenson BC, Beers K, Blankschtein D. Complementary use of simulations and molecular-thermodynamic theory to model micellization. Langmuir. 2006 Feb 14;22(4):1500-13. Review. PubMed PMID: 16460068.
3: Lee BL, Sykes BD, Fliegel L. Structural and functional insights into the cardiac Na⁺/H⁺ exchanger. J Mol Cell Cardiol. 2013 Aug;61:60-7. doi: 10.1016/j.yjmcc.2012.11.019. Epub 2012 Dec 7. Review. PubMed PMID: 23220151.
4: Craik DJ, Daly NL. NMR as a tool for elucidating the structures of circular and knotted proteins. Mol Biosyst. 2007 Apr;3(4):257-65. Epub 2007 Jan 25. Review. PubMed PMID: 17372654.
5: Reingewertz TH, Shalev DE, Friedler A. Structural disorder in the HIV-1 Vif protein and interaction-dependent gain of structure. Protein Pept Lett. 2010 Aug;17(8):988-98. Review. PubMed PMID: 20450485.
6: Neale C, Ghanei H, Holyoake J, Bishop RE, Privé GG, Pomès R. Detergent-mediated protein aggregation. Chem Phys Lipids. 2013 Apr;169:72-84. doi: 10.1016/j.chemphyslip.2013.02.005. Epub 2013 Mar 4. Review. PubMed PMID: 23466535; PubMed Central PMCID: PMC5007131.
7: Mäler L. Solution NMR studies of cell-penetrating peptides in model membrane systems. Adv Drug Deliv Rev. 2013 Jul;65(8):1002-11. doi: 10.1016/j.addr.2012.10.011. Epub 2012 Nov 6. Review. PubMed PMID: 23137785.

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