Dofetilide-d4

• CAT Number: S000426
• CAS Number: 1189700-56-8
• Molecular Formula: C19H23D4N3O5S2
• Molecular Weight: 445.59
• Purity: ≥95%
• IUPAC Name: N-[4-[2-[methyl-[1,1,2,2-tetradeuterio-2-[4-(methanesulfonamido)phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide
• InChI: InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3/i14D2,15D2
• InChIKey: IXTMWRCNAAVVAI-QZPARXMSSA-N
• SMILES: CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C

Dofetilide-d4（Cat No.:S000426） is a deuterated form of dofetilide, where four hydrogen atoms are replaced with deuterium. This modification is crucial for studying the drug’s pharmacokinetics and enhancing its metabolic stability. Dofetilide is a class III antiarrhythmic agent used primarily to treat and prevent various forms of cardiac arrhythmias, including atrial fibrillation and flutter. It works by inhibiting the rapid component of the delayed rectifier potassium current, thereby prolonging the cardiac action potential and refractory period. Dofetilide-d4 allows researchers to explore detailed metabolic pathways and interactions, aiding in the optimization of therapeutic protocols.