Dolutegravir-d3 SR Isomer

• CAT Number: R037202
• CAS Number: NA
• Molecular Formula: C₂₀H₁₆D₃F₂N₃O₅
• Molecular Weight: 422.4
• Purity: ≥95%
• Synonyms: (4S,12aR)-N-(2,4-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1’,2’:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide-d3
• Storage: -20°C
• IUPAC Name: (3R,7S)-5,5,6-trideuterio-N-[(2,4-difluorophenyl)methyl]-11-hydroxy-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-13-carboxamide
• InChI: InChI=1S/C20H19F2N3O5/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28)/t10-,15+/m0/s1/i4D,5D2/t4?,10-,15+
• InChIKey: RHWKPHLQXYSBKR-PYYPGBOJSA-N
• SMILES: [2H]C1[C@@H](N2[C@@H](CN3C=C(C(=O)C(=C3C2=O)O)C(=O)NCC4=C(C=C(C=C4)F)F)OC1([2H])[2H])C

Dolutegravir-d3 SR Isomer is a deuterated form of the Dolutegravir SR (Slow-Release) isomer, featuring three deuterium atoms. This high-purity isotopically labeled compound is crucial for advanced research in HIV pharmacotherapy, drug metabolism, and pharmacokinetics. Dolutegravir is an integrase inhibitor used in the treatment of HIV, and the SR isomer is designed for slow-release formulations, enhancing drug stability and patient compliance. Dolutegravir-d3 SR Isomer is particularly valuable for studying the metabolic pathways, bioavailability, and long-term efficacy of Dolutegravir in clinical settings. The deuterium labeling allows for precise tracking and quantification in biological systems, improving the accuracy of mass spectrometric analyses. This compound is an essential tool for researchers focused on optimizing HIV treatment regimens, drug development, and therapeutic monitoring, offering reliable and consistent results in various experimental applications.