Dolutegravir intermediate-1

• CAT Number: I013020
• CAS Number: 1335210-23-5
• Molecular Formula: C₁₃H₁₇NO₈
• Molecular Weight: 315.28
• Purity: ≥95%
• Target: Others
• Solubility: DMSO
• Storage: Room Temperature
• IUPAC Name: 1-(2,2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid
• InChI: InChI=1S/C13H17NO8/c1-19-8(20-2)6-14-5-7(12(16)17)10(15)11(21-3)9(14)13(18)22-4/h5,8H,6H2,1-4H3,(H,16,17)
• InChIKey: XAXGEECGULRZGN-UHFFFAOYSA-N
• SMILES: COC1=C(N(C=C(C1=O)C(=O)O)CC(OC)OC)C(=O)OC

Dolutegravir intermediate-1（Cat No.:I013020） is a newly developed synthetic intermediate of dolutegravir, extracted from patent WO 2016125192 A2. Dolutegravir is an integrase inhibitor specifically designed for the treatment of human immunodeficiency virus (HIV)-1 infection. As a potent antiretroviral drug, dolutegravir inhibits the action of HIV integrase, preventing viral replication and reducing the viral load in HIV-infected individuals. The discovery of dolutegravir intermediate-1 provides a valuable step forward in the synthesis and production of dolutegravir, contributing to its availability for the management of HIV-1 infections.

Reference

[1]. Sivaram Prasad, et al. Process for the preparation of dolutegravir . WO 2016125192 A2.